期刊
EXPERIMENTAL CELL RESEARCH
卷 319, 期 15, 页码 2343-2349出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.07.024
关键词
Migration; Activation; Leukocytes; Small GTPases; Guanine nucleotide exchange factors
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Society for the Promotion of Science
- CREST program of Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [24111007, 25251015, 24590586] Funding Source: KAKEN
DOCK proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho family of GTPases. Although DOCK family proteins do not contain the Dbl homology domain typically found in GEFs, they mediate the GTP-GDP exchange reaction through DHR-2 domain. Accumulating evidence indicates that the DOCK proteins act as major GEFs in varied biological settings. For example, DOCK2, which is predominantly expressed in hematopoietic cells, regulates migration and activation of leukocytes through Rac activation. On the other hand, it was recently reported that mutations of DOCK8, another member of the DOCK family proteins, cause a combined immunodeficiency syndrome in humans. This article reviews the structure, functions and signaling of DOCK2 and DOCK8, especially focusing on their roles in immune responses. (C) 2013 Elsevier Inc. All rights reserved.
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