期刊
EXPERIMENTAL CELL RESEARCH
卷 319, 期 15, 页码 2384-2394出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.06.016
关键词
Rho GTPases; Neurodegeneration; Neurite outgrowth; RhoGEFs; RhoGAPs; Nerve injury
资金
- CIHR [MOP -14701]
- FRSQ Master's Training Award
Rho GTPases are molecular switches that modulate multiple intracellular signaling processes by means of various effector proteins. As a result, Rho GTPase activities are tightly spatiotemporally regulated in order to ensure homeostasis within the cell. Though the roles of Rho GTPases during neural development have been well documented, their participation during neurodegeneration has been far less characterized. Herein we discuss our current knowledge of the role and function of Rho GTPases and regulators during neurodegeneration, and highlight their potential as targets for therapeutic intervention in common neurodegenerative disorders. (C) 2013 Elsevier Inc. All rights reserved.
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