期刊
EXPERIMENTAL CELL RESEARCH
卷 319, 期 16, 页码 2418-2423出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.04.023
关键词
Cell mechanics; Tissue mechanics; Mechanotransduction; Cell migration; Hill-curve; Acto-myosin interaction
资金
- Deutsche Forschungsgemeinschaft [FA336/2-2]
- National Institutes of Health [HL65960]
Migrating cells generate traction forces to counteract the movement-resisting forces arising from cell-internal stresses and matrix adhesions. In the case of collective migration in a cell colony, or in the case of 3-dimensional migration through connective tissue, movement-resisting forces arise also from external stresses. Although the deformation of a stiffer cell or matrix causes larger movement-resisting forces, at the same time a larger stiffness can also promote cell migration due to a feedback between forces, deformations, and deformation speed that is mediated by the acto-myosin contractile machinery of cells. This mechanical feedback is also important for stiffness sensing, durotaxis, plithotaxis, and collective migration in cell colonies. (C) 2013 Elsevier Inc. All rights reserved.
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