期刊
EXPERIMENTAL CELL RESEARCH
卷 317, 期 5, 页码 620-631出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.12.017
关键词
Chemokines; Chemokine receptors; T cell trafficking
资金
- Australian Government National Health
- Medical Research Counsel and Overseas Biomedical Based Fellowship
- NIH [CA69212]
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naive cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells. CXCR3 is activated by three interferon-inducible ligands CXCL9 (MIG), CXCL10 (IP-10) and CXCL11 (I-TAC). Early studies demonstrated a role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation and the establishment of a Thl amplification loop mediated by IFN gamma and the IFN gamma-inducible CXCR3 ligands. More recent studies have also suggested that CXCR3 plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells. (C) 2011 Elsevier Inc. All rights reserved.
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