期刊
EXPERIMENTAL CELL RESEARCH
卷 317, 期 5, 页码 664-673出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.11.013
关键词
Chemokines; Receptors; Cancer; Inflammation; Macrophages
资金
- Italian Association for Cancer Research (AIRC) Italy
- FP6 European Programme ATTACK
- FP7 European People Programme ATTRACT
- Italian Ministry of Health, University and Research
Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据