期刊
EXPERIMENTAL CELL RESEARCH
卷 317, 期 17, 页码 2490-2502出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2011.07.001
关键词
ICER; Cdk1; Phosphorylation; Ubiquitination
资金
- New Jersey Commission for Cancer Research
In contrast to normal prostatic cells, the transcriptional repressor Inducible cAMP Early Repressor (ICER) is undetected in the nuclei of prostate cancer cells. The molecular mechanisms for ICER abnormal expression in prostate cancer cells remained largely unknown. In this report data is presented demonstrating that ICER is phosphorylated by the mitotic kinase cdk1. Phosphorylation of ICER on a discrete residue targeted ICER to be monoubiquitinated. Different from unphosphorylated, phosphorylated and polyubiquitinated ICER, monoubiquitinated ICER was found to be cytosolic. Taken together, these results hinted on a mechanism for the observed abnormal subcellular localization of ICER in human prostate tumors. (C) 2011 Published by Elsevier Inc.
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