期刊
EXPERIMENTAL CELL RESEARCH
卷 316, 期 8, 页码 1357-1364出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.02.040
关键词
RNA Processing; Post-transcriptional; Untranslated Regions; Genomics; Bioinformatics
资金
- National Cancer Institute
- Cancer Prevention and Research Institute of Texas
- Swedish Cancer Foundation
- Swedish Research Council
- NATIONAL CANCER INSTITUTE [R00CA131474] Funding Source: NIH RePORTER
Precisely directed cleavage and polyadenylation of mRNA is a fundamental part of eukaryotic gene expression. Yet, 3' end heterogeneity has been documented for thousands of mammalian genes, and usage of one cleavage and polyadenylation signal over another has been shown to impact gene expression in many cases. Building upon the rich biochemical and genetic understanding of the 3' end formation, recent genomic studies have begun to suggest that widespread changes in mRNA cleavage and polyadenylation may be a part of large, dynamic gene regulatory programs. In this review, we begin with a modest overview of the studies that defined the mechanisms of mammalian 3' end formation, and then discuss how recent genomic studies intersect with these more traditional approaches, showing that both will be crucial for expanding our understanding of this facet of gene regulation. (C) 2010 Elsevier Inc. All rights reserved.
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