期刊
EXPERIMENTAL CELL RESEARCH
卷 316, 期 5, 页码 728-736出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2009.12.001
关键词
RIP2 (receptor interacting protein 2); Keratinocyte proliferation; Cutaneous wound repair
资金
- Deutsche Forschungsgemeinschaft [Mu 1556 / 3-1]
- Sonnenfeld-Stiftung, Berlin, Germany
We could recently demonstrate an important role of receptor interacting protein 4 (RIP4) in the regulation of keratinocyte differentiation Now, we analyzed a potential role of the RIP4 homolog RIP2 in keratinocytes. Specifically, we demonstrate here that rip2 expression is induced by scratch-wounding and after the induction of differentiation in these cells. Furthermore, serum growth factors and cytokines can induce rip2, with TNF-alpha-dependent induction being dependent on p38 MAPK In addition, we demonstrate that scratch-induced upregulation of rip2 expression is completely blocked by the steroid dexamethasone. Since we also show that RIP2 is an important player in the regulation of keratinocyte proliferation, these data suggest that inhibition of rip2 upregulation after wounding might contribute to the reduced and delayed wound re-epithelialization phenotype seen in glucocorticoid-treated patients (c) 2009 Elsevier Inc All rights reserved
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