The insulin receptor substrate-1: A biomarker for cancer?

This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 Should be considered a biomaker for cancers Susceptible to IGF-IR targeting. In addition, I Would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect Of tumor Suppressors, a Sort of anti-p53 molecule. (C) 2008 Published by Elsevier Inc.