期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 239, 期 7, 页码 773-778出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214531879
关键词
GADD45; cell senescence; cancer
资金
- National Natural Science Foundation of China [81201542]
- Natural Science Foundation of Shanghai [12ZR1430100]
- State Key Laboratory of Oncogenes and Related Genes [91-12-03]
The growth arrest and DNA damage 45 (GADD45) family genes regulate DNA repair, cell cycle, cell survival, apoptosis, senescence, and DNA demethylation in the cells under various stress stimuli, such as oxidative stress, UV radiation, and oncogenic stress. Recent studies have provided important insights regarding how different oncogenic stresses activate GADD45 signaling pathway and lead to disparate influences on tumor initiation. In this review, we discuss the deregulation and cellular function of GADD45 proteins in the context of cancer development. We also highlight recent advances in exploring the tumor suppressive function of GADD45 proteins-triggered cellular senescence.
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