期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 238, 期 5, 页码 525-538出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370213489446
关键词
p62/SQSTM1; autophagy; liver
资金
- NIAAA [R01 AA020518-01]
- National Center for Research Resources [5P20RR021940-07]
- 'Training Program in Environmental Toxicology' from the National Institute of Environmental Health Sciences [5 T32 ES007079]
- Biomedical Research Training Program Fellowship from University of Kansas Medical Center
p62/sequestosome-1/A170/ZIP (hereafter referred to as p62) is a scaffold protein that has multiple functions, such as signal transduction, cell proliferation, cell survival, cell death, inflammation, tumourigenesis and oxidative stress response. While p62 is an autophagy substrate and is degraded by autophagy, p62 serves as an autophagy receptor for selective autophagic clearance of protein aggregates and organelles. Moreover, p62 functions as a signalling hub for various signalling pathways, including NF-kappa B, Nrf2 and mTOR. In this review, we discuss the pathophysiological role of p62 in the liver, including formation of hepatic inclusion bodies, cholestasis, obesity, insulin resistance, liver cell death and tumourigenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据