期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 236, 期 8, 页码 926-937出版社
SOC EXPERIMENTAL BIOLOGY MEDICINE
DOI: 10.1258/ebm.2011.011062
关键词
mathematical model; co-infection; multiple infection; cytotoxic T lymphocytes; escape; immune control
资金
- NIH [R01AI058153-01A2]
- NIAID [A1058876]
- NYU CFAR
The dynamics between human immunodeficiency virus type 1 and the immune system have been studied both experimentally and mathematically, exploring aspects of host adaptation and viral mechanisms to escape host control. The majority of this work, however, has been performed assuming that any cell can only be infected by one copy of the virus. In recent years, it has become clear that multiple copies of the virus can infect the same cell, a process we refer to as co-infection. Here, we review this topic and discuss how immune control of the infection and the ability of the virus to escape immune control is affected by co-infection.
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