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Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms

期刊

EXPERIMENTAL BIOLOGY AND MEDICINE
卷 236, 期 8, 页码 926-937

出版社

SOC EXPERIMENTAL BIOLOGY MEDICINE
DOI: 10.1258/ebm.2011.011062

关键词

mathematical model; co-infection; multiple infection; cytotoxic T lymphocytes; escape; immune control

资金

  1. NIH [R01AI058153-01A2]
  2. NIAID [A1058876]
  3. NYU CFAR

向作者/读者索取更多资源

The dynamics between human immunodeficiency virus type 1 and the immune system have been studied both experimentally and mathematically, exploring aspects of host adaptation and viral mechanisms to escape host control. The majority of this work, however, has been performed assuming that any cell can only be infected by one copy of the virus. In recent years, it has become clear that multiple copies of the virus can infect the same cell, a process we refer to as co-infection. Here, we review this topic and discuss how immune control of the infection and the ability of the virus to escape immune control is affected by co-infection.

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