4.4 Article

Plasma Cytokine Fluctuations over Time in Healthy Controls and Patients with Fibromyalgia

期刊

EXPERIMENTAL BIOLOGY AND MEDICINE
卷 234, 期 2, 页码 232-240

出版社

SAGE PUBLICATIONS LTD
DOI: 10.3181/0808-RM-254

关键词

biological rhythms; ultradian; cytokines; pain

资金

  1. NIH [RO1-AI-54478, R01-AR-43130, M01-RR-002635]
  2. Women's Hospital General Clinical Research Center
  3. American Fibromyalgia Syndrome Association

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We examined the pattern of cytokine secretion across the 24-hr day for women with widespread pain and tenderness having the diagnosis of fibromyalgia (FM) and matched healthy controls. Subjects were given time to habituate to being in a clinical research laboratory environment and then were sampled for cytokines without their being disturbed for a 24-hr period including an 8-hr sleep period. Cytokine levels were uniformly low but characterized by bursts of secretion. Bursting occurred either in singlets or in doublets with a range from 88 to 131 mins between doublet bursts. There was an element of synchronization of these bursts with most occurring at the beginning of sampling. FM patients showed a shift to increased IL-10 in the nighttime compared to controls. The relation between this anti-inflammatory cytokine to the pro-inflammatory cytokines studied also differed between groups: FM patients showed an increased ratio of IL-10 burst amplitude to that of proinflammatory cytokines IL-1 beta, IL-8, and TNF-alpha. We interpret this to indicate a skew away from the normal balance favoring proinflammatory cytokines in controls toward one favoring an anti-inflammatory response in FM. These changes toward anti-inflammatory predominance in FM may explain their common

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