期刊
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
卷 66, 期 4, 页码 179-185出版社
ELSEVIER GMBH
DOI: 10.1016/j.etp.2014.01.002
关键词
Mycotoxin; Spermatozoa; Testes; GST; Carotenoid; Lycopene
资金
- FAPERGS [10/0685-8, 11/1630-1, 1879-25.51/13-6]
- PqG
- CNPq
- FAPERGS
Zearalenone (ZEA) is a mycotoxin commonly found as a contaminant in cereals. ZEA toxicity targets mainly the reproductive system, and oxidative stress plays an etiological role in its toxic effects. Therefore, the present study aimed to investigate the effect of lycopene, a potent carotenoid antioxidant, on markers of oxidative stress in liver, kidney and testes, and on reproductive, hematological and histopathological parameters after ZEA administration. Adult Swiss albino male mice received lycopene (20 mg/kg, p.o.) for ten days before a single oral administration of ZEA (40 mg/kg, p.o,), and 48 h thereafter tissues (liver, kidney, testes and blood) were collected for biochemical, hematological and histological analyses. Lycopene prevented ZEA-induced changes in hematological parameters (increased number of leukocytes, segmented neutrophils, sticks, eosinophils and monocytes and decreased number of red blood cells (RBC), number of lymphocytes and platelets). Moreover, lycopene prevented the reduction in the number and motility of spermatozoa and the testicular tissue damage induced by ZEA. In addition, lycopene prevented the decrease in glutathione-S-transferase activity in kidney and testes and increased glutathione-S-transferase activity per se in the liver, kidneys and testes as well as superoxide dismutase activity in the liver. In summary, lycopene was able to prevent ZEA-induced acute toxic effects in male mice, suggesting that this antioxidant carotenoid may represent a promising prophylactic strategy against ZEA toxicity. (C) 2014 Elsevier GmbH. All rights reserved.
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