期刊
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
卷 64, 期 5, 页码 453-458出版社
ELSEVIER GMBH
DOI: 10.1016/j.etp.2010.10.013
关键词
N(G)-nitro-D-arginine (D-NNA); Salvia miltiorrhiza (SM); Oxidative damage; Nitric oxide (NO); Kidney damage
资金
- Science and Technology Planning Project of Zhejiang Province, China [2008F80001]
- National Natural Science Foundation of China [30901759, 30701064]
- Medical and Health Scientific Research Foundation of Zhejiang Province, China [2009B001]
N(G)-nitro-D-arginine (D-NNA) could convert into N(G)-nitro-L-arginine (L-NNA) in vivo, and kidney is the major target organ. In the chiral inversion process, a number of reactive oxygen species (ROS) were generated and NOS activity was inhibited, which may cause renal damage. Salvia miltiorrhiza (SM), a traditional Chinese drug, was used in the treatment of cardiovascular diseases and chronic renal failure. The aim of the present study was to investigate the kidney damage caused by D-NNA administration for 12 weeks and to evaluate the effects of treatment with SM on D-NNA-induced kidney damage. The rats, induced with D-NNA for period of 12 weeks, showed significant elevation of Blood Urea Nitrogen (BUN), Creatinine (Crea) and MDA levels, and significant decrease of SOD and GSH-Px activities, as compared with control group. In addition, the kidney of rats induced with D-NNA only showed remarkable histopathology, including severe mononuclear cell infiltration, mild tubular dilatation and congestion, and moderate interstitial desmoplasia. After 4 weeks SM treatment, the activity of SOD, GSH-Px and iNOS and the production of NO were significantly higher (P<0.05), and the levels of BUN, Crea and MDA were significantly lower than that of D-NNA only group (P<0.05). In addition, treatment with SM showed histopathological protection in tubular dilatation, congestion, mononuclear cell infiltration and interstitial desmoplasia. The present results indicate that the toxicity of D-NNA relates to its ability to generate oxidative stress and upregulate NOS activity in rat kidney. SM probably ameliorates D-NNA-induced nephrotoxicity in rats according to scavenging free radical and upregulating NOS activity. Crown Copyright (C) 2010 Published by Elsevier GmbH. All rights reserved.
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