期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 26, 期 7, 页码 1059-1067出版社
SPRINGER
DOI: 10.1007/s13361-015-1088-z
关键词
Protein structure; Folding; Gas phase; Electron capture dissociation; Mass spectrometry
资金
- Austrian Science Fund (FWF) [Y372, P27347]
- Austrian Science Fund (FWF) [P 27347, Y 372] Funding Source: researchfish
- Austrian Science Fund (FWF) [P27347] Funding Source: Austrian Science Fund (FWF)
The established methods for the study of atom-detailed protein structure in the condensed phases, X-ray crystallography and nuclear magnetic resonance spectroscopy, have recently been complemented by new techniques by which nearly or fully desolvated protein structures are probed in gas-phase experiments. Electron capture dissociation (ECD) is unique among these as it provides residue-specific, although indirect, structural information. In this Critical Insight article, we discuss the development of ECD for the structural probing of gaseous protein ions, its potential, and limitations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据