期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 85, 期 1, 页码 64-67出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2008.03.008
关键词
microsatellite instability; lynch syndrome; heriditary non-polyposis colorectal cancer; CpG island methylator phenotype; CIMP; BRAF; APC
类别
资金
- NCI [CA48998, CA 61757]
- Dr. Peter Jensen and the Department of Pathology
The genetic heterogeneity of colon cancer suggests that it is actually more than one disease, and perhaps represents a conglomeration of genetically different diseases which happen to occur in the same organ. The progressively more refined genetic definition of colon cancer has uncovered and/or strengthened heretofore obscured associations with clinicopathologic features and risk factors and has led to the development of numerous useful clinical tests, some of which may also have therapeutic implications. It is certainly possible that we have only begun to scratch the surface of this heterogeneity. Other techniques-expression microarray, microRNAs, etc.-will likely add to this heterogeneity and suggest future diagnostic and therapeutic evaluations. In addition, recent data on APC gene mutations challenges the existing paradigm for colon cancer carcinogenesis and precursor lesions, which may in turn have clinical implications for cancer prevention. (c) 2008 Elsevier Inc. All rights reserved.
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