期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 44, 期 7, 页码 432-439出版社
NATURE PUBLISHING GROUP
DOI: 10.3858/emm.2012.44.7.048
关键词
NFAT2; osteoclasts; osteoporosis; ovariectomy; platinum nanoparticles; RANK ligand
资金
- National Research Foundation
- Korean government [BRL-2009-0087350, KRF-2010-0002644]
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)-induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-kappa B ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-kappa B and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca2+ oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
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