期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 26, 期 11, 页码 1931-1937出版社
SPRINGER
DOI: 10.1007/s13361-015-1223-x
关键词
Nanoparticles; Laser desorption/ionization; Inkjet-printing; Amino acids
资金
- NSF [CMMI-1025020]
- SBIR from NASA [NNX12CG18P]
Effective detection of low molecular weight compounds in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is often hindered by matrix interferences in the low m/z region of the mass spectrum. Here, we show that monolayer-protected gold nanoparticles (AuNPs) can serve as alternate matrices for the very sensitive detection of low molecular weight compounds such as amino acids. Amino acids can be detected at low fmol levels with minimal interferences by properly choosing the AuNP deposition method, density, size, and monolayer surface chemistry. By inkjet-printing AuNPs at various densities, we find that AuNP clusters are essential for obtaining the greatest sensitivity.
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