期刊
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
卷 26, 期 6, 页码 582-598出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/pha0000221
关键词
cannabis use; delta-9-tetrahydrocannabinol; functional MRI; tolerance; psychosis
资金
- National Institute for Health Research (NIHR) Clinician Scientist Award [NIHR CS-11-001]
- Medical Research Council [MR/J012149/1]
- MRC [G0501775] Funding Source: UKRI
Cannabis can induce transient psychotic and anxiety symptoms and long-lasting disorders. The acute psychoactive effects of its main active ingredient, (-)-trans-Delta 9-tetrahydrocannabinol (Delta 9-THC), may be modulated by previous cannabis exposure. Secondary data analyses tested whether modest previous cannabis exposure modulated the acute effects of Delta 9-THC on attentional salience and emotional processing and their neurophysiological substrates. Twenty-four healthy men participated in a doubleblind, randomized, placebo-controlled, repeated-measures, within-subject, Delta 9-THC challenge study using fMRI. Compared with nonusers (NUs; n = 12; < 5 lifetime cannabis joints smoked), abstinent-modest cannabis users (CUs; n = 12; 24.5 +/- 9 lifetime cannabis joints smoked) showed less efficient attentional salience processing and recruited different/additional brain areas to process attentional salient and emotional stimuli (all ps < .01). The Delta 9-THC challenge disrupted attentional salience and emotional-processing-related brain activity and induced transient anxiety and psychotic symptoms (all ps <= .02). However, Delta 9-THC-induced psychotic symptoms and attentional salience behavioral impairment were more pronounced in NUs compared with CUs (all ps <= .04). Also, NUs under Delta 9-THC shifted toward recruitment of other brain areas to perform the tasks. Conversely, CUs were less affected by the acute challenge in an exposure-dependent manner, showing a neurophysiological pattern similar to that of NUs under placebo. Only in NUs, Delta 9-THC-induced psychotic symptom and cognitive impairment severity was associated with a more pronounced neurophysiological alteration (all ps <= .048). In conclusion, CUs displayed residual effects of cannabis exposure but more blunted responses to the acute symptomatic, behavioral, and neurophysiological effects of Delta 9-THC, which were more marked in NUs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据