期刊
ACS NANO
卷 9, 期 1, 页码 191-205出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn503450t
关键词
upconversion nanoparticles; titanium dioxide; photodynamic therapy; near-infrared; cancer
类别
资金
- Agency for Science, Technology and Research (A*STAR) Biomedical Engineering Programme [R-397-000-128-305, BMRNI11133]
- NUS graduate school (NGS) for Integrative Sciences and Engineering, National University of Singapore
Because of the limited penetration depth of visible light that generally excites most of the available photosensitizers (PSs), conventional photodynamic therapy (PDT) is limited to the treatment of superficial and flat lesions. Recently, the application of deep penetrating near-infrared (NIR) light excitable upconversion nanoparticles (UCNs) in conjunction with PDT has shown to have clear potential in the treatment of solid tumors due to its ability to penetrate thick tissue. However, various constructs developed so far have certain limitations such as poor or unstable PS loading, reducing their therapeutic efficacy and limiting their application to solution or cell-based studies. In this work, we present a method to fabricate uniform core-shell structured nanoconstruct with a thin layer of photocatalyst or PS-titanium dioxide (TiO2) stably coated on individual UCN core. Our design allows controllable and highly reproducible PS loading, preventing any leakage of PS compared to previously developed nanoconstructs, thus ensuring repeatable PDT results. Further surface modification of the developed nanoconstructs with polyethylene glycol (PEG) rendered them biocompatible, demonstrating good therapeutic efficacy both in vitro and in vivo.
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