期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 42, 期 2, 页码 45-52出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000012
关键词
muscle atrophy; myosin heavy-chain coexpression; denervation; skeletal muscle; fiber type; aging; sarcopenia
资金
- Canadian Institutes of Health Research [MOP125986, MOP119583]
- Fonds de Recherche Quebec-Sante
- McGill University
It is accepted widely that fast-twitch muscle fibers are preferentially impacted in aging muscle, yet we hypothesize that this is not valid when aging muscle atrophy becomes severe. In this review, we summarize the evidence of fiber type-specific effect in aging muscle and the potential confounding roles of fibers coexpressing multiple myosin heavy-chain isoforms and their histochemical identification.
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