期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 41, 期 3, 页码 162-168出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3182948a1e
关键词
antioxidants; cardioprotection; phytochemicals; oxidative stress; exercise
资金
- U.S. Department of Agriculture, Colorado State Agricultural Experiment Station
- Defense Advanced Research Projects Agency (DARPA) [N66001-10-c-2134]
Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.
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