The Role of Adenosine Monophosphate Kinase in Remodeling White Adipose Tissue Metabolism

GAIDHU, M.P. and R.B. CEDDIA. The role of adenosine monophosphate kinase in remodeling white adipose tissue metabolism. Exerc. Sport Sci. Rev., Vol. 39, No. 2, pp. 102-108, 2011. Recent evidence indicates that the enzyme adenosine monophosphate (AMP) kinase exerts important fat-reducing effects in the adipose tissue, which has created great interest in this enzyme as a potential target for obesity treatment. This review summarizes our findings that chronic AMP kinase activation remodels adipocyte glucose and lipid metabolism and enhances the ability of adipose tissue to dissipate energy within itself and reduce adiposity.