期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 38, 期 3, 页码 114-121出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3181e3728f
关键词
leptin; insulin; ghrelin; motivation; reward; obesity
资金
- National Institutes of Health [R15 DK066286, DK20572, M01-RR00042]
BORER, K.T. Nonhomeostatic control of human appetite and physical activity in regulation of energy balance. Exerc. Sport Sci. Rev., Vol. 38, No. 3, pp. 114-121, 2010. Ghrelin and leptin, putative controllers of human appetite, have no effect on human meal-to-meal appetite but respond to variations in energy availability. Nonhomeostatic characteristics of appetite and spontaneous activity stem from inhibition by leptin and ghrelin of brain reward circuit that is responsive to energy deficit, but refractory in obesity, and from the operation of a meal-timing circadian clock.
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