期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 37, 期 1, 页码 18-22出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e318190ebdb
关键词
myogenic cells; macrophage activation; tissue repair; inflammation; phagocytosis
资金
- INSERM
- University Paris 12
- Association Francaise centre les Myopathies
- Fondation de France
CHAZAUD, B., M. BRIGITTE, H. YACOUB-YOUSSEF, L. ARNOLD, R. GHERARDI, C. SONNET, P. LAFUSTE, and F. CHRETIEN. Dual and beneficial roles of macrophages during skeletal muscle regeneration. Exerc. Sport Sci. Rev., Vol. 37, No. 1, pp. 18-22, 2009. Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.
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