期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 36, 期 2, 页码 51-57出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e318168e9dc
关键词
atrophy; mitochondria; skeletal myofiber; satellite cells; signaling proteins
资金
- NIA NIH HHS [R01 AG021530-04, R01 AG021530, R01 AG-021530, R01 AG021530-03] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG021530] Funding Source: NIH RePORTER
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.
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