期刊
EVOLUTIONARY APPLICATIONS
卷 7, 期 10, 页码 1161-1179出版社
WILEY
DOI: 10.1111/eva.12221
关键词
drug resistance; eco-evolutionary feedback; environmental change; experimental evolution; infectious disease; mathematical model; spatiotemporal heterogeneity; standing genetic variation
资金
- European Research Council under the 7th Framework Programme of the European Commission ('PBDR') [268540]
- ANR EVORANGE [ANR-09-PEXT-011]
- ANR SilentAdapt [ANR 100517]
- RTRA BIOFIS [INRA 065609]
- SNF Ambizione [PZ00P3_137514]
Evolutionary responses that rescue populations from extinction when drastic environmental changes occur can be friend or foe. The field of conservation biology is concerned with the survival of species in deteriorating global habitats. In medicine, in contrast, infected patients are treated with chemotherapeutic interventions, but drug resistance can compromise eradication of pathogens. These contrasting biological systems and goals have created two quite separate research communities, despite addressing the same central question of whether populations will decline to extinction or be rescued through evolution. We argue that closer integration of the two fields, especially of theoretical understanding, would yield new insights and accelerate progress on these applied problems. Here, we overview and link mathematical modelling approaches in these fields, suggest specific areas with potential for fruitful exchange, and discuss common ideas and issues for empirical testing and prediction.
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