期刊
EVOLUTIONARY APPLICATIONS
卷 6, 期 1, 页码 102-108出版社
WILEY
DOI: 10.1111/eva.12017
关键词
disease Biology; evolutionary Medicine; natural selection and contemporary evolution
资金
- Kay Kendall Leukaemia Fund
- Leukaemia & Lymphoma Research UK
Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain competitive advantage via their fitness in relation to micro-environmental selective pressures. In this context, the unit of selection is the cell, but not any cell. The so-called cancer stem cells have the essential properties required to function as the key units of selection, particularly with respect to their proliferative potential and longevity. These cells drive evolutionary progression of disease and provide reservoirs for relapse or recurrence and drug resistance. They represent the prime, but elusive and moving, targets for therapeutic control.
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