期刊
EVOLUTION
卷 65, 期 11, 页码 3175-3194出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1558-5646.2011.01369.x
关键词
EST-SSR; heterozygosity-fitness correlation; identity disequilibrium; microsatellites; population structure
资金
- German Research Foundation [MU 1479/2-1]
- Max Planck Society
To understand the mechanisms behind heterozygosity-fitness correlations (HFC), it is necessary to employ large numbers of markers with known function and independently estimate the variation in inbreeding in the population. Here we genotyped 794 blue tits with 79 microsatellites that were distributed across 25 chromosomes and that were classified either as functional (N = 58) or neutral (N = 21). We found a positive effect of individual heterozygosity at multiple loci on clutch size, on the number of eggs sired by males, and on the number of recruits produced by males and females. We documented the occurrence of some consanguineous matings and found evidence for a particular type of population structure that can contribute to the occurrence of inbreeding. As the set of neutral loci provided more power to detect HFC and identity disequilibrium, we argue that neutral markers are better predictors of the effects of inbreeding. The number of significant effects at single loci did not exceed the expected number of false positives and no strong effects were associated with heterozygosity at functional markers. Thus, the HFC found here cannot be attributed to strong effects of the loci under study.
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