期刊
EVOLUTION
卷 65, 期 4, 页码 1149-1162出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1558-5646.2010.01186.x
关键词
Dengue; introgression; malaria; maternal effect; mosquito; population replacement
资金
- NIH [R01-AI54954-0IA2, R01 GM072879, R01 GM070956, DP1 OD003878]
- Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative
- Weston Havens Foundation
One strategy for controlling transmission of insect-borne disease involves replacing the native insect population with transgenic animals unable to transmit disease. Population replacement requires a drive mechanism to ensure the rapid spread of linked transgenes, the presence of which may result in a fitness cost to carriers. Medea selfish genetic elements have the feature that when present in a female, only offspring that inherit the element survive, a behavior that can lead to spread. Here, we derive equations that describe the conditions under which Medea elements with a fitness cost will spread, and the equilibrium allele frequencies are achieved. Of particular importance, we show that whenever Medea spreads, the non-Medea genotype is driven out of the population, and we estimate the number of generations required to achieve this goal for Medea elements with different fitness costs and male-only introduction frequencies. Finally, we characterize two contexts in which Medea elements with fitness costs drive the non-Medea allele from the population: an autosomal element in which not all Medea-bearing progeny of a Medea-bearing mother survive, and an X-linked element in species in which X/Y individuals are male. Our results suggest that Medea elements can drive population replacement under a wide range of conditions.
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