期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/813672
关键词
-
资金
- National Science Council [NSC 102-2325-B-003-001, NSC 102-2321-B-003-004]
- Ministry of Science and Technology [MOST 103-2325-B-003-003, MOST 103-2321-B-003-003, MOST 103-2320-B-436-001]
- National Taiwan Normal University [103T3040B07]
- Mackay Junior College of Medicine, Nursing and Management [MKC102R06]
- Ministry of Science and Technology
Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phosphotau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer's disease (3xTg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the A beta deposition and p-tau (S202/S262) levels in the hippocampus of 3xTg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.
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