Predicting 5-and 10-Year Survival in Older Women with Early-Stage Breast Cancer: Self-Rated Health and Walking Ability

ObjectivesTo determine life expectancy for older women with breast cancer. DesignProspective longitudinal study with 10years of follow-up data. SettingHospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island). ParticipantsWomen aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N=615; 17% aged 80, 52% Stage I, 58% with 2 comorbidities). MeasurementsBaseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival. ResultsAt the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5years, P.001; 0.300 vs 0.648 at 10years, P<.001). There were no differences between the groups in breast cancer-specific survival at 5 and 10years (P = .66 at 5years, P=.16 at 10years). ConclusionThe combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer.