期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/638723
关键词
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资金
- National Basic Research Program of China (973 Program) [2003CB 517105, 2011CB505106]
- Creation for Significant New Drugs [2009ZX09502-018]
- International Science and Technology Cooperation of China [2008DFA30610]
- National Science Foundation of China [81102730, 30902020, 81173463]
- Foundation of Beijing University of Chinese Medicine of Education Ministry of China [2011JYBZZ-JS090, 2011-CXTD-06]
- ministry of education [NCET-11-0607]
- Beijing science & technology star [2011069]
The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models. GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA). 30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group. 21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value. Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients. Independent Student's t-test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data. The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.
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