期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/548430
关键词
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资金
- National Basic Research Program of China 973 [2012CB517600, 2012CB517602]
- National Natural Science Foundation of China [NSFC 81025025, J1103512]
- Jiangsu Natural Science Foundation [BK 2010365]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1020]
Hyperuricemia and dyslipidemia are involved in Cd nephrotoxicity. The aim of this study was to determine the effect of quercetin, a dietary flavonoid with anti-hyperuricemic and anti-dyslipidemic properties, on the alteration of renal UA transport system and disorder of renal lipid accumulation in 3 and 6 mg/kg Cd-exposed rats for 4 weeks. Cd exposure induced hyperuricemia with renal XOR hyperactivity and UA excretion dysfunction in rats. Simultaneously, abnormal expression levels of renal UA transport-related proteins including RST, OAT1, MRP4 and ABCG2 were observed in Cd-exposed rats with inhibitory activity of renal Na+-K+-ATPase. Furthermore, Cd exposure disturbed lipid metabolism with down-regulation of AMPK and its downstream targets PPAR alpha, OCTN2 and CPT1 expressions, and up-regulation of PGC-1 beta and SREBP-1 expressions in renal cortex of rats. We had proved that Cd-induced disorder of renal UA transport and production system might have cross-talking with renal AMPK-PPAR alpha/PGC-1 beta signal pathway impairment, contributing to Cd nephrotoxicity of rats. Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPAR alpha/PGC-1 beta signal pathway, resulting in renal lipid accumulation reduction of rats.
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