期刊
EUROPEAN RESPIRATORY JOURNAL
卷 45, 期 3, 页码 610-624出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00083614
关键词
-
资金
- European Community Seventh Framework Programme (FP7) [211250]
- Asthma UK
- J.P. Moulton Charitable Foundation
- UK Medical Research Council [G0601361, MR/K002449/1]
- North West Lung Centre Charity
- Federal Ministry for Education, Science, Research and Technology (interventional arm)
- Helmholtz Zentrum Munich (formerly GSF)
- Federal Ministry for Environment (IUF) [FKZ 20462296]
- Federal Ministry for Education, Science, Research and Technology
- Helmholtz Zentrum Munich, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Marien-Hospital Wesel
- Swedish Heart-Lung Foundation
- Konsul Th. C. Bergh Foundation
- Stockholm County Council
- Swedish Asthma and Allergy Association Research Foundation
- Swedish Foundation for Health Care Sciences and Allergy Research
- Swedish Environmental Protection Agency
- Netherlands Organization for Health Research and Development
- Netherlands Organization for Scientific Research
- Netherlands Asthma Fund
- Netherlands Ministry of Spatial Planning, Housing, and the Environment
- Netherlands Ministry of Health, Welfare, and Sport
- Medical Research Council [G0601361, MR/K002449/2, MR/K002449/1] Funding Source: researchfish
- MRC [MR/K002449/2, MR/K002449/1, G0601361] Funding Source: UKRI
The aim of this study was to determine the effect of six traffic-related air pollution metrics (nitrogen dioxide, nitrogen oxides, particulate matter with an aerodynamic diameter <10 mu m (PM10), PM2.5, coarse particulate matter and PM2.5 absorbance) on childhood asthma and wheeze prevalence in five European birth cohorts: MAAS (England, UK), BAMSE (Sweden), PIAMA (the Netherlands), GINI and LISA (both Germany, divided into north and south areas). Land-use regression models were developed for each study area and used to estimate outdoor air pollution exposure at the home address of each child. Information on asthma and current wheeze prevalence at the ages of 4-5 and 8-10 years was collected using validated questionnaires. Multiple logistic regression was used to analyse the association between pollutant exposure and asthma within each cohort. Random-effects meta-analyses were used to combine effect estimates from individual cohorts. The meta-analyses showed no significant association between asthma prevalence and air pollution exposure (e.g. adjusted OR (95%CI) for asthma at age 8-10 years and exposure at the birth address (n=10377): 1.10 (0.81-1.49) per 10 mu g.m(-3) nitrogen dioxide; 0.88 (0.63-1.24) per 10 mu g.m(-3) PM10; 1.23 (0.78-1.95) per 5 mu g.m(-3) PM2.5). This result was consistently found in initial crude models, adjusted models and further sensitivity analyses. This study found no significant association between air pollution exposure and childhood asthma prevalence in five European birth cohorts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据