期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 66, 期 14, 页码 1615-1624出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2015.08.025
关键词
cardiometabolic diseases; diabetes; fructose; obesity
资金
- National Institutes of Health [P30 DK46200, HL60712]
- Metagenics
- California Walnut Commission
Recent attention has focused on fructose as having a unique role in the pathogenesis of cardiometabolic diseases. However, because we rarely consume fructose in isolation, the major source of fructose in the diet comes from fructose-containing sugars, sucrose and high fructose corn syrup, in sugar-sweetened beverages and foods. Intake of sugar-sweetened beverages has been consistently linked to increased risk of obesity, type 2 diabetes, and cardiovascular disease in various populations. Putative underlying mechanisms include incomplete compensation for liquid calories, adverse glycemic effects, and increased hepatic metabolism of fructose leading to de novo lipogenesis, production of uric acid, and accumulation of visceral and ectopic fat. In this review we summarize the epidemiological and clinical trial evidence evaluating added sugars, especially sugar-sweetened beverages, and the risk of obesity, diabetes, and cardiovascular disease and address potential biological mechanisms with an emphasis on fructose physiology. We also discuss strategies to reduce intake of fructose-containing beverages. (C) 2015 by the American College of Cardiology Foundation.
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