期刊
EUROPEAN RESPIRATORY JOURNAL
卷 38, 期 6, 页码 1310-1319出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00006911
关键词
Asthma; longitudinal study; randomised clinical trial; vitamin A
资金
- Bill and Melinda Gates Foundation (Seattle, WA, USA)
- Sight and Life Research Institute (Baltimore)
- Johns Hopkins University
- National Heart, Lung and Blood Institutes (Baltimore) [K99HL096955]
- Johns Hopkins University [HRN-A-00-97-00015-00]
- Office of Health, Infectious Diseases and Nutrition of the US Agency for International Development (Washington, DC, USA) [HRN-A-00-97-00015-00]
- Task Force Sight and Life (Basel, Switzerland)
Animal models suggest that vitamin A deficiency affects lung development adversely and promotes airway hyperresponsiveness, and may predispose to an increased risk of asthma. We examined the long-term effects of vitamin A supplementation early in life on later asthma risk. In 2006-2008, we revisited participants from two cohorts in rural Nepal who were enrolled in randomised trials of vitamin A supplementation. The first cohort received vitamin A or placebo for <16 months during their pre-school years (1989-1991). The second cohort was born to mothers who received vitamin A, beta-carotene or placebo before, during and after pregnancy (1994-1997). At follow-up, we asked about asthma symptoms and performed spirometry. Out of 6,421 subjects eligible to participate, 5,430 (85%) responded to our respiratory survey. Wheezing prevalence during the previous year was 4.8% in participants aged 9-13 yrs and 6.6% in participants aged 14-23 yrs. We found no differences between the vitamin A supplemented and placebo groups from either trial in the prevalence of lifetime or current asthma and wheeze or in spirometric indices of obstruction (p >= 0.12 for all comparisons). Vitamin A supplementation early in life was not associated with a decreased risk of asthma in an area with chronic vitamin A deficiency.
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