期刊
EUROPEAN RESPIRATORY JOURNAL
卷 37, 期 6, 页码 1360-1365出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00164609
关键词
Asthma; asthma epidemiology; asthma onset; stressful life events
资金
- Academy of Finland [110451, 117604, 124271, 128089, 129262, 124322]
- BUPA Foundation, UK
- National Institute on Agin [R01AG034454]
- National Heart, Lung, and Blood Institute, NIH, USA [R01HL036310]
- EU
- MRC [G0902037] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G8802774, G0100222, G19/35, G0902037] Funding Source: researchfish
The status of stressful life events as a risk factor for asthma is unclear and may be dependent on pre-existing allergic rhinitis. This study examined whether exposure to stressful life events predicted the onset of asthma in adults. This is a prospective, population-based cohort study of 16,881 males and females, aged 20-54 yrs and free of diagnosed asthma at the beginning of the follow-up (January 1, 2004). Data about stressful life events were gathered with a postal survey. The onset of asthma was ascertained through national registers until December 31, 2005. During the follow-up period, 192 incident cases of asthma were identified. High total exposure to stressful life events, as indicated by a cumulative severity score, predicted the onset of asthma (hazard ratio 1.96, 95% CI 1.22-3.13). This association was robust to adjustment for demographics, smoking and having a cat/dog at home and it was observed both among those with and without allergic rhinitis at baseline. Of the 10 most stressful life events, the illness of a family member, marital problems, divorce or separation and conflicts with a supervisor were associated with the onset of asthma. Our study suggests that stressful life events may increase the onset of asthma.
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