期刊
EUROPEAN RADIOLOGY
卷 24, 期 11, 页码 2962-2970出版社
SPRINGER
DOI: 10.1007/s00330-014-3251-5
关键词
DWI; Signal Intensity; Complete Response; Chemoradiotherapy; Locally Advanced Rectal Cancer
资金
- Nature Science Foundation of China [81101591]
- Natural Science Foundation of Guangdong Province, China [S2011040005278, 9151008901000157]
- Science and Technology Planning Project of Guangdong Province, China [2010B060900043]
- Medical Scientific Research Foundation of Guangdong Province, China [WSTJJ20101107440520197505093916]
To determine diagnostic performance of simple measurements on diffusion-weighted MR imaging (DWI) for assessment of complete tumour response (CR) after neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC) by signal intensity (SI) and apparent diffusion coefficient (ADC) measurements. Sixty-five patients with LARC who underwent neoadjuvant CRT and subsequent surgery were included. Patients underwent pre-CRT and post-CRT 3.0 T MRI. Regions of interest of the highest brightness SI were included in the tumour volume on post-CRT DWI to calculate the SIlesion, rSI, ADC(lesion) and rADC; diagnostic performance was compared by using the receiver operating characteristic (ROC) curves. In order to validate the accuracy and reproducibility of the current strategy, the same procedure was reproduced in 80 patients with LARC at 1.5 T MRI. Areas under the ROC curve for identification of a CR, based on SIlesion, rSI, ADC(lesion), and rADC, respectively, were 0.86, 0.94, 0.66, and 0.71 at 3.0 T MRI, and 0.92, 0.91, 0.64, and 0.61 at 1.5 T MRI. Post-CRT DWI SIlesion and rSI provided high diagnostic performance in assessing CR and were significantly more accurate than ADC(lesion), and rADC at 3.0 T MRI and 1.5 T MRI. aEuro cent Signal intensity (SI (lesion) ) and rSI are accurate for assessment of complete response. aEuro cent rSI seems to be superior to SI (lesion) at 3.0 T MRI. aEuro cent ADC or rADC measurements are not accurate for assessment of complete response.
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