期刊
EUROPEAN RADIOLOGY
卷 22, 期 7, 页码 1451-1464出版社
SPRINGER
DOI: 10.1007/s00330-012-2446-x
关键词
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); Tumour vasculature; Angiogenesis; Cancer; Early phase trials
资金
- Cancer Research UK
- National Institute for Health Research in England
- Department of Health for Scotland
- Department of Health for Wales
- Department of Health for Northern Ireland
- AstraZeneca
- Pfiizer
- GSK
- Roche
- Genentech
- Bayer
- Merck-Serono
- Philips Medical Systems
- Cancer Research UK [10337] Funding Source: researchfish
- Medical Research Council [G0701945] Funding Source: researchfish
- MRC [G0701945] Funding Source: UKRI
Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. image acquisition and analysis) can be performed effectively and with consistency among contributing centres. As the technique continues to develop in order to provide potential improvements in sensitivity and physiological relevance, there is considerable scope for between-centre variation in techniques. A workshop was convened by the Imaging Committee of the Experimental Cancer Medicine Centres (ECMC) to review the current status of DCE-MRI and to provide recommendations on how the technique can best be used for early stage trials. This review and the consequent recommendations are summarised here. Key Points aEuro cent Tumour vascular function is key to tumour development and treatment aEuro cent Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumour vascular function aEuro cent Thus DCE-MRI with pharmacokinetic models can assess novel treatments aEuro cent Many recent developments are advancing the accuracy of and information from DCE-MRI aEuro cent Establishing common methodology across multiple centres is challenging and requires accepted guidelines.
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