期刊
EUROPEAN RADIOLOGY
卷 22, 期 12, 页码 2633-2640出版社
SPRINGER
DOI: 10.1007/s00330-012-2544-9
关键词
Breast; Magnetic resonance imaging; Contrast media; Oral contraceptives; Postmenopausal hormone therapy
资金
- Federal Ministry of Education and Research [03ZIK012]
- Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- Bayer Healthcare
Objectives To investigate effects of menopausal status, oral contraceptives (OC), and postmenopausal hormone therapy (HT) on normal breast parenchymal contrast enhancement (CE) and non-mass-like enhancing areas in magnetic resonance mammography (MRM). Methods A total of 459 female volunteers (mean age 49.1 +/- 12.5 years) underwent T1-weighted 3D MRM 1-5 min after bolus injection of gadobutrol. Quantitative analysis was performed in normal breast parenchyma by manually tracing regions of interest and calculating percentage CE. Semiquantitative analysis was performed in non-mass-like enhancing areas, and signal intensity changes were characterised by five predefined kinetic curve types. The influence of OC (n = 69) and HT (n = 24) on CE was studied using random effects models. Results Breast parenchymal enhancement was significantly higher in premenopausal than in postmenopausal women (P < 0.001). CE decreased significantly with the use of OC (P = 0.01), while HT had negligible effects (P = 0.52). Prevalence of kinetic curve types of non-mass-like enhancement differed strongly between pre- and postmenopausal women (P < 0.0001), but was similar in OC users and non-OC users (P = 0.61) as well as HT users and non-HT users (P = 0.77). Conclusions Normal breast parenchymal enhancement and non-mass-like enhancing areas were strongly affected by menopausal status, while they were not affected by HT use and only moderately by OC use. Key Points . Breast parenchymal enhancement at MR mammography is stronger in premenopausal than postmenopausal women. . The prevalence of strong enhancing non-mass-like areas is greater before menopause. . Such enhancing non-mass-like areas may impair lesion detection in premenopausal women. . Breast parenchymal enhancement is only marginally affected by hormone use. . Discontinuation of hormone use before MR mammography may be unnecessary.
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