期刊
EUROPEAN RADIOLOGY
卷 20, 期 3, 页码 674-682出版社
SPRINGER
DOI: 10.1007/s00330-009-1581-5
关键词
Alzheimer's disease; Mild cognitive impairment; MRI; Neuropsychology; Dementia
资金
- UK Department of Health's National Institute of Health Research Biomedical Research Centres
- National Institute of Ageing, the National Institute of Biomedical Imaging and Bioengineering (NBIB)
- Foundation of the National Institutes of Health
- Medical Research Council (UK)
- Alzheimer's Research Trust (UK)
- Kirby Laing Foundation
- Technology Strategy Board Grant
- Alzheimers Research UK [ART-RF2007-1] Funding Source: researchfish
- Medical Research Council [G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
- MRC [G0601846] Funding Source: UKRI
To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers.
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