期刊
EUROPEAN PSYCHIATRY
卷 29, 期 3, 页码 117-124出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1016/j.eurpsy.2013.07.004
关键词
Alcohol use disorders; Bipolar disorder; Comorbidity; Co-occurrence
类别
资金
- Medical Research Council [MR/L010305/1, MR/K023233/1, G0801418B] Funding Source: researchfish
- MRC [MR/K023233/1] Funding Source: UKRI
Aims: To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. Methods: Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. Results: In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. Conclusion: AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs. (C) 2013 Elsevier Masson SAS. All rights reserved.
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