期刊
EUROPEAN PSYCHIATRY
卷 25, 期 5, 页码 284-286出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2010.01.007
关键词
Suicide; Adolescents; Timing; Gene environment interaction; Imaging; Polymorphism
类别
Suicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults. (C) 2010 Elsevier Masson SAS. All rights reserved.
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