期刊
EUROPEAN POLYMER JOURNAL
卷 48, 期 4, 页码 696-704出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2012.01.011
关键词
Poly(L-glutamic acid); Star-block copolymer; Drug delivery system; pH-responsive
资金
- National Natural Science Foundation of China [50973058]
- Natural Science Foundation of Guangdong Province [9351503102000001]
- Science Foundation of Shantou University Medical College for Distinguished Undergraduates
Star-block copolymers PEI-g-(PLG-b-PEG), which consist of a hyperbranched polyethylenimine (PEI) core, a poly(t-glutamic acid) (PLC) inner shell, and a poly(ethylene glycol) (PEG) outer shell, were synthesised and evaluated as nanocarriers for cationic drugs. The synthesised star-block copolymers were characterised by H-1 NMR, gel permeation chromatography (GPC), dynamic light scattering (DES), and transmission electron microscopy (TEM). Crystal violet (CV), as a model cationic dye, and doxorubicin hydrochloride (DOX), as a model anticancer drug, could be efficiently entrapped by the synthesised star-block copolymers at physiological pH as a result of electrostatic interactions between the cationic guest molecules and the negatively charged PLC segments in the PEI-g-(PLG-b-PEG) host. The drug-polymer complexes showed relatively high temporal stability at physiological pH and sustained release of the encapsulated drugs was observed. The entrapped model compounds demonstrated accelerated release as the pH was gradually decreased. (C) 2012 Elsevier Ltd. All rights reserved.
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