期刊
EUROPEAN POLYMER JOURNAL
卷 44, 期 11, 页码 3715-3723出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2008.08.016
关键词
2-(Dimethylamino)ethyl methacrylate; Star-shaped polymer; ATRP; Viscometry; DLS; AFM
资金
- WALEO 2 Program CARCINOM
- DGTRE
- Region Wallonne
- European Commission
- Belgian Federal Government Office of Science Policy [PAI 6/27]
- FNRS/FRFC
Novel synthetic transfection vectors with linear triblock and star-shaped diblock copolymer architectures have been synthesized by atom transfer radical polymerization (ATRP). Based on 2-(dimethylamino)ethyl methacrylate (DMAEMA) and copolymerization with poly(ethyleneglycol) a-methoxy, omega-methacrylate (MAPEG), the synthesis was realized using CuBr ligated with 1,1,4,7,10,10-hexamethyltriethylenetetramine (HMTETA) as catalytic complex and either ethyl 2-bromoisobutyrate ((EBB)-B-i) or bis(alpha-bromoisobutyryl) N-methyl diethanolamine (DEA) or tris(alpha-bromoisobutyryl) triethanolamine (TEA) as (multifunctional)initiator. The polymers were characterized by GPC and NMR. The solution properties of these homopolymers and palm-tree-like copolymers were investigated by viscometry either in pure water or in buffered aqueous solutions. Interestingly, all the synthesized polymers show polyelectrolyte effect in Millipore water (25 degrees C) and in Hepes (20 mM) buffer solution (pH 7.4, NaCl 155 mM, 25 degrees C). Fitting of these viscometric data according to either Fuoss or Fedors equation allows for calculating the intrinsic viscosity of the polymers. These results are compared with dynamic light scattering (DLS) experiments to determine absolute masses. Finally, DEA based palm-tree-like copolymer is investigated to AFM measurement and micelles were observed at pH 8. (C) 2008 Elsevier Ltd. All rights reserved.
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