期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 24, 期 11, 页码 1850-1854出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2014.09.004
关键词
Cocaine pharmacology; Serotonin transporter knockout rats; Microdialysis; Seratonin release; Nucleus accumbens; Hippocarnpus
资金
- ECNP research grant
It has recently been proposed that the increased reinforcing properties of cocaine and ecstasy observed in rats with a genetic deletion of serotonin transporters are the result of a reduction in the psychostimulant-induced release of serotonin. Here we provide the neurochemical evidence in favor of this hypothesis and show that changes in synaptic levels of dopamine or noradrenaline are not very likely to play an important role in the previously reported enhanced psychostimulant intake of these serotonin transporter knockout rats. The results may very well explain why human subjects displaying a reduced expression of serotonin transporters have an increased risk to develop addiction. (C014 Elsevier B.V. and ECNP. All rights reserved.
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