期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 24, 期 2, 页码 207-214出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2013.09.007
关键词
Depression; Cardiopulmonary coupling; Bupropion; Sleep quality
资金
- National Institutes of Health [RO1 DA014037, RO1 DA015131, RO1 DA017804, RO1 DA017805, RO1 MH062464, RO1 MH068391, G12 RR003032, UL1 RR024975, U54 RR026140/U54 MD007593]
- Endowed Chair in Brain and Behavior Research at Meharry Medical College
Depression could be an independent risk factor for cardiovascular disease. We assessed bupropion response in depressed patients by polysomnography (PSG) and cardiopulmonary coupling (CPC) variables. Nineteen subjects participated in a two-session, two consecutive night PSG protocol. Participants received either placebo or bupropion-SR 150 mg, orally, in a randomized, double-blind cross-over fashion on night two. Outcome variables were: sleep stages, REM latency, stable, unstable sleep and very low frequency coupling (VLFC). CPC analysis uses heart rate variability and the electrocardiogram's R-wave amplitude fluctuations associated with respiration to generate frequency maps. Bupropion increased REM latency (p=0.043) but did not impact PSG sleep continuity, architecture and CPC variables. A trend (p=0.092) was observed towards increasing VLFC duration. Bupropion increased the number of stable-unstable sleep transitions (p=0.036). Moderate to strong correlations between PSG and CPC variables were found on placebo and bupropion nights. Limitations include a small sample size, limited power to detect CPC changes and lack of normal controls for comparison. Increased stable-unstable sleep transitions and VLFC duration may indicate vulnerability to cardiovascular disease due to their association with low heart rate variability that has been associated with increased mortality raising the question whether the beneficial effects of the antidepressant medication outweighs the impact on cardiopulmonary dynamics. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.
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