期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 23, 期 11, 页码 1423-1431出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2013.05.012
关键词
Tourette syndrome; Obsessive-compulsive disorder; Dopamine; Amphetamine; Positron emission tomography; [C-11]raclopride
资金
- National Tourette Syndrome Association of the USA
Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) both are neuropsychiatric disorders associated with abnormalities in dopamine neurotransmission. Aims of this study were to quantify striatal D-2/3 receptor availability in IS and OCD, and to examine dopamine release and symptom severity changes in both disorders following amphetamine challenge. Changes in [C-11]raclopride binding potential (BPND) were assessed using positron emission tomography before and after administration of D-amphetamine (0.3 mg kg(-1)) in 12 TS patients without comorbid OCD, 12 OCD patients without comorbid tics, and 12 healthy controls. Main outcome measures were baseline striatal D-2/3 receptor BPND and change in BPND following amphetamine as a measure of dopamine release. Voxel-based analysis revealed significantly decreased baseline [C-11]raclopride BPND in bilateral putamen of both patient groups vs. healthy controls, differences being more pronounced in the TS than in the OCD group. Changes in BPND following amphetamine were not significantly different between groups. Following amphetamine administration, tic severity increased in the TS group, which correlated with BPND changes in right ventral striatum. Symptom severity in the OCD group did not change significantly following amphetamine challenge and was not associated with changes in BPND. This study provides evidence for decreased striatal D-2/3 receptor availability in TS and OCD, presumably reflecting higher endogenous dopamine levels in both disorders. In addition, it provides the first direct evidence that ventral striatal dopamine release is related to the pathophysiology of tics. (C) 2013 Elsevier B.V. and ECNR All rights reserved.
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